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KMID : 0616120170480010010
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Korean Journal of Pharmacognosy
2017 Volume.48 No. 1 p.10 ~ p.17
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Biological Activities of Ursi Fel`s Component Ursodeoxycholic Acid and Its Derivatives
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Cha Bae-Cheon
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Abstract
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Ursi Fel`s component ursodeoxycholic acid (UDCA), a traditional medicine, is used for the treatment of hepatic diseases. UDCA derivatives prepared by conjugation with antioxidant moiety such as maltol, sesamol, eugenol, mesitol and 3,4- (methylenedeoxy)aniline were expected to have various biological activity caused by synergistic effect of UDCA. Therefore, in this study, it was conducted the study of the manufacture of the UDCA derivatives and their biological activity. As a result, UDCA derivatives showed weak antioxidant activity in TBA method in vitro compared to original agents. SJ-505, SJ-502 and SJ-504 showed the effect of reducing ALT, AST, sorbitol dehydrogenase and γ-glutamyltransferase in CCl4-induced liver injury experiment in vivo, even if the effects are weaker than UDCA and silymarin of the control group.
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KEYWORD
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Ursodeoxycholic acid (UDCA), Maltol, Sesamol, Eugenol, Mesitol, 3, 4-(Methylenedeoxy)aniline, UDCA derivatives, Antioxidant, Hepatic protective effect
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